Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | BCR | P11274 | 1/20 | 0.57 |
| ▸ | CD38 | P28907 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30559792 | 0.88 | ABL1 (0.57) | ABL1BCRKMT2ACYP2D6CYP1A2 | |
| SCHEMBL6402301 | 0.73 | ABL1 (1.00) | ABL1BCRCCNT1CCNE1CDK2 | |
| SCHEMBL14785920 | 0.70 | KMT2A (0.51) | CD38KMT2ACYP2D6CYP1A2CYP3A4 | |
| SCHEMBL13355296 | 0.69 | CD38 (0.49) | CD38KMT2ACYP1A2CYP2C19CYP2C9 | |
| SCHEMBL4912541 | 0.69 | KMT2A (0.61) | CD38KMT2ACYP2D6CYP1A2CYP3A4 | |
| SCHEMBL9521235 | 0.66 | CYP3A4 (0.58) | ABL1BCRCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL30038452 | 0.66 | CD38 (1.00) | CD38 | |
| SCHEMBL1891250 | 0.66 | KDR (0.70) | — | |
| SCHEMBL27193043 | 0.64 | RAB9A (0.50) | KMT2ACYP1A2CYP2C19CYP2C9CDK9 | |
| SCHEMBL11539010 | 0.64 | KMT2A (0.67) | CD38KMT2ACYP2D6CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784650-B1 | N-PHENYL-N'-(4-{[6-(1H-IMIDAZOL-1-YL)-4-PYRIMIDINYL]AMINO}PHENYL)UREA DERIVATIVES AS MCT4 INHIBITORS FOR THE TREATMENT OF CANCER | CHARLES R DREW UNIV OF MEDICINE AND SCIENCE (US) | 2023-09-06 | — | — | EP | disclosed |
| CN-112888673-B | Novel MCT4 inhibitors and uses thereof | 查尔斯德鲁医药科学大学 | 2022-07-29 | — | — | CN | disclosed |
| CN-112888673-A | Novel MCT4 inhibitors and uses thereof | 查尔斯德鲁医药科学大学 | 2021-06-01 | — | — | CN | disclosed |
| US-10919878-B2 | MCT4 inhibitors and uses thereof | CHARLES R. DREW UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2021-02-16 | — | — | US | disclosed |
| US-10919878-B2 | MCT4 inhibitors and uses thereof | CHARLES R. DREW UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2021-02-16 | — | — | US | disclosed |
| WO-2020033019-A2 | NOVEL MCT4 INHIBITORS AND USES THEREOF | CHARLES R. DREW UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2020-02-13 | — | — | WO | disclosed |
| US-20190352282-A1 | NOVEL MCT4 INHIBITORS AND USES THEREOF | CHARLES R. DREW UNIVERSITY OF MEDICINE AND SCIENCE | 2019-11-21 | — | — | US | disclosed |
| US-20190352282-A1 | NOVEL MCT4 INHIBITORS AND USES THEREOF | CHARLES R. DREW UNIVERSITY OF MEDICINE AND SCIENCE | 2019-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10919878-B2 | MCT4 inhibitors and uses thereof | SLC16A3, SLC16A1, SLC16A7 | ABL1 1659/4885BCR 1706/4885CD38 1364/4885 |
| US-20190352282-A1 | NOVEL MCT4 INHIBITORS AND USES THEREOF | SLC16A3, SLC16A1, SLC16A8 | ABL1 2263/4885BCR 1463/4885CD38 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.