Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17389142 | 0.77 | CHEK1 (0.45) | PIM1ROCK1DRD1LMNAPOLB | |
| SCHEMBL17433048 | 0.77 | ALDH1A1 (0.59) | JAK2ABL1PIM1CDK8GSK3A | |
| SCHEMBL29829135 | 0.71 | POLB (0.68) | MAPK1LMNAPOLBCYP1A2ALDH1A1 | |
| SCHEMBL17017090 | 0.71 | POLB (0.68) | MAPK1LMNAPOLBCYP1A2ALDH1A1 | |
| SCHEMBL29363298 | 0.70 | POLB (0.50) | MAPK8GSK3AROCK1MAPK1LMNA | |
| SCHEMBL16655562 | 0.70 | POLB (0.50) | MAPK8GSK3AROCK1MAPK1LMNA | |
| SCHEMBL15266863 | 0.69 | LRRK2 (0.56) | PIM1DYRK1AMAPK1 | |
| SCHEMBL28701478 | 0.68 | MAPT (0.50) | ROCK1LMNAPOLBCYP1A2SLC29A1 | |
| SCHEMBL13006154 | 0.68 | ALDH1A1 (0.39) | DRD1PIK3CALMNAPOLBTDO2 | |
| SCHEMBL29366544 | 0.68 | MAPT (0.50) | ROCK1LMNAPOLBCYP1A2SLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023160652-A1 | SUBSTITUTED FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR AND USES THEREOF | 苏州亚宝药物研发有限公司 | 2023-08-31 | — | — | WO | disclosed |