Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 11/20 | 0.55 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.55 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | DRD5 | P21918 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059420 | 0.89 | DRD2 (0.52) | KMT2AABCB1ABCC1ABCG2REV1 | |
| SCHEMBL3058994 | 0.86 | REV1 (0.64) | KMT2AABCB1ABCC1ABCG2REV1 | |
| SCHEMBL3051734 | 0.82 | KDM4E (0.67) | KMT2AABCB1ABCC1ABCG2KDM4E | |
| SCHEMBL3051924 | 0.80 | REV1 (0.77) | KMT2AABCB1ABCC1ABCG2REV1 | |
| SCHEMBL7743501 | 0.78 | FNTA (0.54) | KMT2AABCB1ABCC1ABCG2REV1 | |
| SCHEMBL3050450 | 0.78 | KMT2A (0.55) | KMT2AABCB1ABCC1ABCG2REV1 | |
| SCHEMBL3052578 | 0.77 | ABCB1 (0.53) | KMT2AABCB1ABCC1ABCG2REV1 | |
| SCHEMBL3057840 | 0.77 | KDM4E (0.55) | ABCB1ABCC1ABCG2KDM4ETDP1 | |
| SCHEMBL3059010 | 0.76 | KMT2A (0.50) | KMT2AABCB1ABCC1ABCG2REV1 | |
| SCHEMBL3050446 | 0.76 | KDM4E (0.51) | KMT2AABCB1ABCC1ABCG2REV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | claimed |
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
| EP-2155192-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | Sterix Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008117061-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222299-A1 | COMPOUND | MKI67, VHL, MYC | KMT2A 924/4885ABCB1 754/4885ABCC1 3119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.