Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | CASP6 | P55212 | 2/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25384654 | 1.00 | MEN1 (0.53) | MEN1KMT2AL3MBTL1LMNAPOLB | |
| SCHEMBL31595638 | 1.00 | MEN1 (0.53) | MEN1KMT2AL3MBTL1LMNAPOLB | |
| SCHEMBL25384652 | 1.00 | MEN1 (0.53) | MEN1KMT2AL3MBTL1LMNAPOLB | |
| SCHEMBL30567125 | 1.00 | MEN1 (0.53) | MEN1KMT2AL3MBTL1LMNAPOLB | |
| SCHEMBL25387247 | 1.00 | MEN1 (0.53) | MEN1KMT2AL3MBTL1LMNAPOLB | |
| SCHEMBL25386863 | 0.89 | L3MBTL1 (0.55) | MEN1KMT2AL3MBTL1LMNAPOLB | |
| SCHEMBL31256617 | 0.89 | L3MBTL1 (0.55) | MEN1KMT2AL3MBTL1LMNAPOLB | |
| SCHEMBL31595464 | 0.89 | L3MBTL1 (0.55) | MEN1KMT2AL3MBTL1LMNAPOLB | |
| SCHEMBL25386868 | 0.89 | L3MBTL1 (0.55) | MEN1KMT2AL3MBTL1LMNAPOLB | |
| SCHEMBL26263870 | 0.85 | ANPEP (0.52) | MEN1KMT2AL3MBTL1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250171404-A1 | PCNA INHIBITORS AND USES THEREOF | UNITED STATES GOVERNMENT | 2025-05-29 | — | — | US | disclosed |
| EP-4490142-A2 | PCNA INHIBITORS AND USES THEREOF | City of Hope (US) | 2025-01-15 | — | — | EP | disclosed |
| CN-119013247-A | PCNA inhibitor and use thereof | 希望之城 | 2024-11-22 | — | — | CN | disclosed |
| WO-2023172880-A2 | PCNA INHIBITORS AND USES THEREOF | CITY OF HOPE (US) | 2023-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250171404-A1 | PCNA INHIBITORS AND USES THEREOF | PCNA, MKI67, PCLAF | MEN1 1794/4885KMT2A 1014/4885L3MBTL1 1817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.