Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.52 |
| ▸ | CALCRL | Q16602 | 4/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | CALCR | P30988 | 4/20 | 0.49 |
| ▸ | REN | P00797 | 2/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30495768 | 0.91 | MAPK8 (0.60) | KDM1AMAPK8MAPK9MAPK10MAOB | |
| SCHEMBL29479825 | 0.90 | MAPK8 (0.59) | KDM1AMAPK8MAPK9MAPK10MAOB | |
| SCHEMBL30872251 | 0.86 | MAPK8 (0.58) | MAPK8MAPK9MAPK10CALCRLREN | |
| SCHEMBL38662816 | 0.86 | MAPK8 (0.56) | KDM1AMAPK8MAPK9MAPK10CALCRL | |
| SCHEMBL31497329 | 0.85 | CALCRL (0.62) | KDM1ACALCRLKEAP1 | |
| SCHEMBL29466227 | 0.85 | KDM1A (0.57) | KDM1AMAPK8MAPK9MAPK10MAOB | |
| SCHEMBL30880893 | 0.85 | MAPK8 (0.54) | KDM1AMAPK8MAPK9MAPK10MAOB | |
| SCHEMBL31071032 | 0.84 | CALCRL (0.55) | MAPK8MAPK9MAPK10CALCRLKEAP1 | |
| SCHEMBL31497351 | 0.83 | KEAP1 (0.60) | KDM1ACALCRLKEAP1 | |
| SCHEMBL30824279 | 0.83 | CALCR (0.55) | KDM1AMAOBKDM5AKDM1BCALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240277841-A2 | HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-08-22 | — | — | US | disclosed |
| US-20240024473-A1 | HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE | PURDUE RESEARCH FOUNDATION (US) | 2024-01-25 | — | — | US | disclosed |
| CN-116601290-A | Human chimeric antigen receptor neutrophils, compositions, kits and methods of use | 普渡研究基金会 | 2023-08-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240277841-A2 | HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE | PBK, KIT, MYD88 | KDM1A 2261/4885MAPK8 1290/4885MAPK9 1320/4885 |
| US-20240024473-A1 | HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE | PBK, KIT, MYD88 | KDM1A 2261/4885MAPK8 1290/4885MAPK9 1320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.