Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21941112 | 0.88 | TSHR (0.38) | GPR119TSHRALOX15NAMPTATM | |
| SCHEMBL29506188 | 0.88 | TSHR (0.38) | GPR119TSHRALOX15NAMPTATM | |
| SCHEMBL29506184 | 0.88 | TSHR (0.38) | GPR119TSHRALOX15NAMPTATM | |
| SCHEMBL29832328 | 0.88 | TSHR (0.38) | GPR119TSHRALOX15NAMPTATM | |
| SCHEMBL21940374 | 0.88 | TSHR (0.38) | GPR119TSHRALOX15NAMPTATM | |
| SCHEMBL24282593 | 0.88 | GPR119 (0.39) | GPR119TSHRALOX15NOTCH1NAMPT | |
| SCHEMBL29550726 | 0.88 | GPR119 (0.39) | GPR119TSHRALOX15NOTCH1NAMPT | |
| SCHEMBL29551015 | 0.88 | GPR119 (0.39) | GPR119TSHRALOX15NOTCH1NAMPT | |
| SCHEMBL23046171 | 0.88 | GPR119 (0.39) | GPR119TSHRALOX15NOTCH1NAMPT | |
| SCHEMBL24635800 | 0.87 | GPR119 (0.39) | GPR119TSHRALOX15NAMPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359642-A | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-111566104-B | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-117143079-A | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-111138412-B | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2023-09-15 | — | — | CN | disclosed |