Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRPS1 | P60891 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25345315 | 1.00 | PRPS1 (0.41) | PRPS1MAPTSMN1; SMN2MEN1HTT | |
| SCHEMBL25344167 | 0.84 | PRPS1 (0.42) | PRPS1MAPTSMN1; SMN2MEN1HTT | |
| SCHEMBL30568608 | 0.84 | PRPS1 (0.42) | PRPS1MAPTSMN1; SMN2MEN1HTT | |
| SCHEMBL30568651 | 0.83 | SSTR4 (0.45) | PRPS1MAPTSMN1; SMN2MEN1HTT | |
| SCHEMBL25343063 | 0.83 | SSTR4 (0.45) | PRPS1MAPTSMN1; SMN2MEN1HTT | |
| SCHEMBL25346349 | 0.81 | USP30 (0.35) | GBA1TRPV4ALDH1A1PDK2 | |
| SCHEMBL30568483 | 0.81 | USP30 (0.35) | GBA1TRPV4ALDH1A1PDK2 | |
| SCHEMBL25344501 | 0.81 | AAK1 (0.34) | NPSR1GBA1FPR3FPR2TRPV4 | |
| SCHEMBL25343570 | 0.81 | PRPS1 (0.39) | PRPS1MAPTSMN1; SMN2MEN1HTT | |
| SCHEMBL25346053 | 0.81 | PRPS1 (0.46) | PRPS1MAPTSMN1; SMN2MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |