Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26607013 | 1.00 | KMT2A (0.57) | KMT2APOLBL3MBTL1LMNAGAA | |
| SCHEMBL2710816 | 0.83 | KMT2A (0.53) | KMT2APOLBLMNAGAAMEN1 | |
| SCHEMBL5031966 | 0.81 | LMNA (0.56) | KMT2APOLBL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL30368270 | 0.80 | KMT2A (0.50) | KMT2APOLBLMNAGAAMEN1 | |
| SCHEMBL16896918 | 0.76 | NPC1 (0.74) | KMT2AL3MBTL1LMNAGAAMEN1 | |
| SCHEMBL30573043 | 0.76 | ACP1 (0.47) | KMT2APOLBLMNAGAAMEN1 | |
| SCHEMBL26606902 | 0.76 | ACP1 (0.47) | KMT2APOLBLMNAGAAMEN1 | |
| SCHEMBL308447 | 0.75 | L3MBTL1 (0.69) | KMT2APOLBL3MBTL1LMNAMEN1 | |
| SCHEMBL7904920 | 0.75 | KMT2A (0.71) | KMT2APOLBL3MBTL1LMNAGAA | |
| SCHEMBL2711919 | 0.75 | KMT2A (0.49) | KMT2APOLBL3MBTL1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4511114-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| WO-2023205778-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |