Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26105927 | 1.00 | KEAP1 (0.47) | KEAP1NFE2L2MAP2K1CYP3A4MAP2K2 | |
| SCHEMBL29715184 | 0.85 | MAP2K1 (0.39) | KEAP1NFE2L2MAP2K1CYP3A4KDM4E | |
| SCHEMBL23496860 | 0.85 | MAP2K1 (0.39) | KEAP1NFE2L2MAP2K1CYP3A4KDM4E | |
| SCHEMBL29376622 | 0.82 | KEAP1 (0.52) | KEAP1NFE2L2MAP2K1CYP3A4KDM4E | |
| SCHEMBL2434231 | 0.82 | KEAP1 (0.52) | KEAP1NFE2L2MAP2K1CYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL10563667 | 0.80 | KEAP1 (0.50) | KEAP1NFE2L2MAP2K1CYP3A4KDM4E | |
| SCHEMBL26108862 | 0.79 | SOS1 (0.46) | KDM4EALDH1A1SMN1; SMN2CA1CA2 | |
| SCHEMBL30574277 | 0.79 | SOS1 (0.46) | KDM4EALDH1A1SMN1; SMN2CA1CA2 | |
| SCHEMBL7596205 | 0.78 | KEAP1 (0.48) | KEAP1NFE2L2MAP2K1CYP3A4KDM4E | |
| SCHEMBL12931099 | 0.78 | KEAP1 (0.40) | KEAP1NFE2L2MAP2K1CYP3A4MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122029168-A | Methods for preparing KRAS G12C inhibitors | 伊莱利利公司 | 2026-05-12 | — | — | CN | disclosed |
| WO-2025080631-A1 | PROCESS FOR MAKING A KRAS G12C INHIBITOR | ELI LILLY AND COMPANY (US) | 2025-04-17 | — | — | WO | disclosed |
| CN-119546309-A | Methods of treatment comprising KRAS G12C inhibitors and AURORA a inhibitors | 伊莱利利公司 | 2025-02-28 | — | — | CN | disclosed |
| EP-4504710-A1 | PROCESS FOR MAKING A KRAS G12C INHIBITOR | Eli Lilly and Company (US) | 2025-02-12 | — | — | EP | disclosed |
| EP-4504209-A1 | METHOD OF TREATMENT INCLUDING KRAS G12C INHIBITORS AND AURORA A INHIBITORS | Eli Lilly and Company (US) | 2025-02-12 | — | — | EP | disclosed |
| CN-119343334-A | Methods of making KRAS G12C inhibitors | 伊莱利利公司 | 2025-01-21 | — | — | CN | disclosed |
| WO-2023196887-A1 | METHOD OF TREATMENT INCLUDING KRAS G12C INHIBITORS AND AURORA A INHIBITORS | ELI LILLY AND COMPANY (US) | 2023-10-12 | — | — | WO | disclosed |
| WO-2023196959-A1 | PROCESS FOR MAKING A KRAS G12C INHIBITOR | ELI LILLY AND COMPANY (US) | 2023-10-12 | — | — | WO | disclosed |