Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25385144 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1POLBRAB9AHDAC8 | |
| SCHEMBL25384316 | 0.89 | PPARG (0.40) | SMN1; SMN2NPC1POLBRAB9AFFAR1 | |
| SCHEMBL30574845 | 0.89 | PPARG (0.40) | SMN1; SMN2NPC1POLBRAB9AFFAR1 | |
| SCHEMBL25385433 | 0.88 | MAOB (0.37) | SMN1; SMN2HDAC8PTPN1PPARDSLC2A1 | |
| SCHEMBL30574828 | 0.88 | MAOB (0.37) | SMN1; SMN2HDAC8PTPN1PPARDSLC2A1 | |
| SCHEMBL25385011 | 0.84 | ALDH1A1 (0.40) | SMN1; SMN2NPC1POLBRAB9AHDAC8 | |
| SCHEMBL30574764 | 0.84 | ALDH1A1 (0.40) | SMN1; SMN2NPC1POLBRAB9AHDAC8 | |
| SCHEMBL30574832 | 0.83 | PTGS1 (0.48) | SMN1; SMN2NPC1POLBRAB9AFFAR1 | |
| SCHEMBL25385232 | 0.83 | PTGS1 (0.48) | SMN1; SMN2NPC1POLBRAB9AFFAR1 | |
| SCHEMBL31056350 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1POLBRAB9ARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4486390-A1 | COVALENT MODIFIERS OF AKT1 AND USES THEREOF | Terremoto Biosciences, Inc (US) | 2025-01-08 | — | — | EP | disclosed |
| WO-2023168291-A1 | COVALENT MODIFIERS OF AKT1 AND USES THEREOF | TERREMOTO BIOSCIENCES, INC. (US) | 2023-09-07 | — | — | WO | disclosed |