Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13806634 | 1.00 | KDM4E (0.41) | KDM4EMAPTALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL9691428 | 0.83 | KDM4E (0.38) | KDM4EMAPTALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL1532459 | 0.83 | ALDH1A1 (0.36) | MAPTALDH1A1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL31008793 | 0.83 | TSHR (0.38) | KDM4EALDH1A1TSHRKMT2AGABRP | |
| SCHEMBL30296925 | 0.83 | ALDH1A1 (0.36) | MAPTALDH1A1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL3461163 | 0.83 | TSHR (0.38) | KDM4EALDH1A1TSHRKMT2AGABRP | |
| SCHEMBL27864943 | 0.81 | SMN1; SMN2 (0.36) | KDM4EMAPTALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL23340379 | 0.80 | GABRP (0.45) | KDM4EMAPTALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL1082565 | 0.79 | HCAR2 (0.41) | KDM4EMAPTALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL4973075 | 0.78 | GSK3B (0.34) | ALDH1A1KMT2ANPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230286958-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286958-A1 | PLASMA KALLIKREIN INHIBITORS | KLKB1, SERPINE1, KLK5 | KDM4E 1074/4885MAPT 781/4885ALDH1A1 1701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.