Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 5/20 | 0.70 |
| ▸ | GLA | P06280 | 3/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | HTR3A | P46098 | 1/20 | 0.70 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | HK1 | P19367 | 1/20 | 0.60 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | NCF1 | P14598 | 3/20 | 0.58 |
| ▸ | APAF1 | O14727 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | UBE2N | P61088 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11817813 | 1.00 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDGLAGAA | |
| Hydrochloric Acid SCHEMBL30576212 | 0.98 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDGLAGAA | |
| SCHEMBL742359 | 0.85 | KDM4E (0.94) | ALDH1A1KDM4EHPGDGLAGAA | |
| SCHEMBL30547000 | 0.85 | KDM4E (0.94) | ALDH1A1KDM4EHPGDGLAGAA | |
| SCHEMBL3641196 | 0.84 | KDM4E (0.97) | ALDH1A1KDM4EHPGDGLAGAA | |
| SCHEMBL11741104 | 0.83 | HRH4 (1.00) | ALDH1A1KDM4EHPGDGLAGAA | |
| SCHEMBL30513776 | 0.83 | HRH4 (1.00) | ALDH1A1KDM4EHPGDGLAGAA | |
| SCHEMBL11739391 | 0.81 | KDM4E (1.00) | ALDH1A1KDM4EHPGDGLAGAA | |
| SCHEMBL1083762 | 0.81 | RAB9A (0.77) | ALDH1A1KDM4EHPGDGLAGAA | |
| Hydrochloric Acid SCHEMBL11738196 | 0.81 | HRH4 (0.97) | ALDH1A1KDM4EHPGDGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4476211-A1 | ACYLATED HETEROCYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | Enliven Inc. (US) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023154124-A1 | ACYLATED HETEROCYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |