Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30576198 | 0.99 | CHRNB2 (0.41) | CHRNB2CHRNA4DCPSPRKCZHTR1A | |
| SCHEMBL29109427 | 0.78 | KDM4E (0.49) | DCPSSLC6A2KCNH2 | |
| SCHEMBL30513804 | 0.77 | HRH4 (0.52) | DCPSHTR1ASLC6A2KCNH2 | |
| SCHEMBL29849730 | 0.76 | KDM4E (0.44) | DCPS | |
| SCHEMBL30513760 | 0.75 | CHRM4 (0.51) | DCPS | |
| SCHEMBL6617419 | 0.72 | MKNK1 (0.41) | CHRNB2CHRNA4ROCK1ROCK2KCNH2 | |
| SCHEMBL5464152 | 0.71 | CHRNB2 (0.49) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL16416180 | 0.71 | HTR6 (0.46) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL2723948 | 0.70 | CHRNB2 (0.48) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL2722697 | 0.70 | CHRNB2 (0.48) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4476211-A1 | ACYLATED HETEROCYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | Enliven Inc. (US) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023154124-A1 | ACYLATED HETEROCYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |