Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 11/20 | 0.65 |
| ▸ | TGM2 | P21980 | 1/20 | 0.62 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.61 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.61 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.57 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | RNASEL | Q05823 | 2/20 | 0.55 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.54 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.54 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.54 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.52 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29657998 | 0.94 | KRAS (0.65) | KRASTGM2TAS1R3TAS1R1FUT5 | |
| SCHEMBL29793878 | 0.94 | KRAS (0.64) | KRASTGM2TAS1R3TAS1R1FUT5 | |
| SCHEMBL26882941 | 0.88 | TAS1R3 (0.65) | KRASTGM2TAS1R3TAS1R1FUT5 | |
| SCHEMBL26632570 | 0.88 | TAS1R3 (0.65) | KRASTGM2TAS1R3TAS1R1FUT5 | |
| SCHEMBL26632575 | 0.88 | TAS1R3 (0.65) | KRASTGM2TAS1R3TAS1R1FUT5 | |
| SCHEMBL26883118 | 0.88 | TAS1R3 (0.65) | KRASTGM2TAS1R3TAS1R1FUT5 | |
| SCHEMBL17824390 | 0.88 | TAS1R3 (0.61) | KRASTGM2TAS1R3TAS1R1NT5E | |
| SCHEMBL31724981 | 0.87 | TAS1R3 (0.66) | KRASTGM2TAS1R3TAS1R1FUT5 | |
| SCHEMBL1620402 | 0.86 | TGM2 (0.69) | KRASTGM2TAS1R3TAS1R1FUT5 | |
| SCHEMBL1620396 | 0.86 | TGM2 (0.69) | KRASTGM2TAS1R3TAS1R1FUT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4476221-A1 | FUSED PYRIMIDINES AS KRAS INHIBITORS | Bayer Aktiengesellschaft (DE) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023152255-A1 | FUSED PYRIMIDINES AS KRAS INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-08-17 | — | — | WO | disclosed |