Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | GPR3 | P46089 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | TNKS | O95271 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.61 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | IDE | P14735 | 1/20 | 0.50 |
| ▸ | MPI | P34949 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13738861 | 1.00 | PARP1 (0.61) | PARP1KDM4EALDH1A1LMNAGPR3 | |
| SCHEMBL2552450 | 0.86 | KDM4E (0.59) | PARP1KDM4EALDH1A1LMNAGPR3 | |
| SCHEMBL30577488 | 0.86 | KDM4E (0.59) | PARP1KDM4EALDH1A1LMNAGPR3 | |
| SCHEMBL4555852 | 0.79 | ALDH1A1 (0.59) | PARP1KDM4EALDH1A1LMNAGPR3 | |
| SCHEMBL21384427 | 0.78 | ALDH1A1 (0.53) | PARP1KDM4EALDH1A1LMNAGPR3 | |
| SCHEMBL8873438 | 0.76 | PARP1 (0.74) | PARP1KDM4EALDH1A1LMNAGPR3 | |
| SCHEMBL30090619 | 0.76 | PARP1 (1.00) | PARP1KDM4EALDH1A1LMNAGPR3 | |
| SCHEMBL17293 | 0.76 | PARP1 (1.00) | PARP1KDM4EALDH1A1LMNAGPR3 | |
| SCHEMBL31326568 | 0.76 | PARP1 (1.00) | PARP1KDM4EALDH1A1LMNAGPR3 | |
| SCHEMBL29593478 | 0.76 | PARP1 (1.00) | PARP1KDM4EALDH1A1LMNAGPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4490161-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND THE USE THEREOF | Impact Therapeutics (Shanghai), Inc. (CN) | 2025-01-15 | — | — | EP | claimed |
| CN-119013279-A | Substituted tricyclic compounds as PARP inhibitors and uses thereof | 上海瑛派药业有限公司 | 2024-11-22 | — | — | CN | claimed |
| WO-2023169226-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND THE USE THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2023-09-14 | — | — | WO | claimed |
| EP-4490161-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND THE USE THEREOF | Impact Therapeutics (Shanghai), Inc. (CN) | 2025-01-15 | — | — | EP | disclosed |
| WO-2025008012-A1 | PYRROLOQUINOLINES AND THEIR USE AS TUBULINE ASSEMBLY INHIBITORS | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2025-01-09 | — | — | WO | disclosed |
| CN-119013279-A | Substituted tricyclic compounds as PARP inhibitors and uses thereof | 上海瑛派药业有限公司 | 2024-11-22 | — | — | CN | disclosed |
| WO-2023169226-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND THE USE THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2023-09-14 | — | — | WO | disclosed |