Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 4/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3049396 | 0.85 | GRM1 (0.39) | GRM1BDKRB1KDM4EHTR2AHTR2C | |
| SCHEMBL13139568 | 0.84 | GRM1 (0.41) | GRM1BDKRB1KDM4EHTR2AHTR2C | |
| SCHEMBL2878484 | 0.83 | GRM1 (0.38) | GRM1BDKRB1KDM4EHTR2AHTR2C | |
| SCHEMBL3042441 | 0.83 | GRM1 (0.42) | GRM1BDKRB1KDM4EHTR2AHTR2C | |
| SCHEMBL3042444 | 0.81 | POLB (0.42) | GRM1BDKRB1KDM4EHTR2AHTR2C | |
| SCHEMBL3047445 | 0.81 | HTR2A (0.41) | GRM1BDKRB1KDM4EHTR2AHTR2C | |
| SCHEMBL3058010 | 0.80 | GRM1 (0.40) | GRM1BDKRB1KDM4EHTR2AHTR2C | |
| SCHEMBL3061732 | 0.71 | HTR2A (0.43) | BACE1HTR2AHTR2CHTR2BKMT2A | |
| SCHEMBL3050577 | 0.70 | BDKRB1 (0.60) | BDKRB1SMN1; SMN2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL3051491 | 0.69 | BDKRB1 (0.58) | BDKRB1SMN1; SMN2CYP2D6CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | GRM1 779/4885BACE1 1078/4885BDKRB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.