Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3043088 | 0.85 | HTR2A (0.42) | HTR2AHTR2CHTR2BGRM1BDKRB1 | |
| SCHEMBL13139563 | 0.84 | HTR2C (0.44) | HTR2AHTR2CHTR2BGRM1NR1H4 | |
| SCHEMBL3052259 | 0.83 | KMO (0.52) | HTR2AHTR2CHTR2BGRM1BDKRB1 | |
| SCHEMBL3058009 | 0.81 | GRM1 (0.39) | HTR2AHTR2CHTR2BGRM1NR1H4 | |
| SCHEMBL3047446 | 0.80 | HTR2C (0.47) | HTR2AHTR2CHTR2BGRM1BDKRB1 | |
| SCHEMBL13139535 | 0.80 | HTR2C (0.42) | HTR2AHTR2CHTR2BGRM1NR1H4 | |
| SCHEMBL13113414 | 0.78 | HTR2C (0.48) | HTR2AHTR2CHTR2BGRM1BDKRB1 | |
| SCHEMBL2878296 | 0.75 | PARP1 (0.45) | HTR2CHTR2BGRM1PARP1POLB | |
| SCHEMBL10086367 | 0.73 | TP53 (0.66) | HTR2AHTR2CHTR2BGRM1BDKRB1 | |
| SCHEMBL3056043 | 0.73 | HTR2C (0.42) | HTR2AHTR2CHTR2BGRM1BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492559-B2 | Substituted indole compounds | GRUENENTHAL GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100222324-A1 | Substituted Indole Compounds | GRUENENTHAL GMBH (DE) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222324-A1 | Substituted Indole Compounds | BDKRB1, BDKRB2, EDNRB | HTR2A 85/4885HTR2C 221/4885HTR2B 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.