SCHEMBL30580205

SCHEMBL30580205

N[C@@H](CO)c1cccc(OC(F)(F)F)c1

nearest known ligand 0.53

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 1/20 0.43
CETP P11597 1/20 0.43
SLC6A2 P23975 6/20 0.41
SCN9A Q15858 2/20 0.41
EPHX1 P07099 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25370020 1.00 TRPM8 (0.43) TRPM8CETPSLC6A2SCN9AEPHX1
SCHEMBL22952738 0.88 TRPM8 (0.41) TRPM8CETPSLC6A2EPHX1
Hydrochloric Acid SCHEMBL28712851 0.86 SLC6A2 (0.41) TRPM8CETPSLC6A2
Hydrochloric Acid SCHEMBL28712853 0.86 SLC6A2 (0.41) TRPM8CETPSLC6A2
SCHEMBL734938 0.85 KIF11 (0.43) TRPM8CETPSLC6A2
SCHEMBL20792262 0.84 SLC7A5 (0.46) TRPM8CETPSLC6A2
SCHEMBL1728053 0.84 SLC6A2 (0.41) TRPM8SLC6A2
SCHEMBL14980651 0.84 ANPEP (0.47) TRPM8CETPSLC6A2
SCHEMBL12261520 0.84 SLC6A2 (0.41) TRPM8SLC6A2
SCHEMBL1729766 0.84 SLC6A2 (0.41) TRPM8SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4479377-A1 NEW BICYCLOPENTANE DERIVATIVES Icagen, LLC (US) 2024-12-25 EP disclosed
WO-2023158584-A1 NEW BICYCLOPENTANE DERIVATIVES ICAGEN, LLC (US) 2023-08-24 WO disclosed