SCHEMBL30582824

SCHEMBL30582824

O=C(COc1ccc2c(c1)OCO2)N(Cc1cccs1)c1ccccn1

nearest known ligand 0.72

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 15/20 0.72
▸ SMN1; SMN2 Q16637 2/20 0.49
▸ HSD17B10 Q99714 1/20 0.49
▸ NPC1 O15118 1/20 0.49
▸ RAB9A P51151 1/20 0.49
▸ CYP1A2 P05177 1/20 0.48
▸ CYP3A4 P08684 1/20 0.48
▸ CYP2C9 P11712 1/20 0.48
▸ CYP2C19 P33261 1/20 0.48
▸ GAA P10253 1/20 0.48
▸ TP53 P04637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2729909 1.00 TRPM8 (0.72) TRPM8SMN1; SMN2HSD17B10NPC1RAB9A
SCHEMBL2729280 0.87 TRPM8 (0.70) TRPM8TP53
SCHEMBL2730876 0.84 TRPM8 (1.00) TRPM8NPC1RAB9A
SCHEMBL2729893 0.84 TRPM8 (0.70) TRPM8NPC1RAB9ATP53
SCHEMBL6400864 0.84 TRPM8 (0.74) TRPM8SMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL2718096 0.83 TRPM8 (0.83) TRPM8SMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL30582823 0.83 TRPM8 (0.83) TRPM8SMN1; SMN2CYP1A2CYP3A4CYP2C9
SCHEMBL2719225 0.83 TRPM8 (0.79) TRPM8SMN1; SMN2GAATP53
SCHEMBL30582810 0.83 TRPM8 (0.79) TRPM8SMN1; SMN2GAATP53
SCHEMBL6407099 0.82 TRPM8 (0.68) TRPM8SMN1; SMN2NPC1RAB9ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025132323-A1 COMPOSITIONS COMPRISING A SUNSCREEN ACTIVE AGENT DSM-FIRMENICH AG (CH) 2025-06-26 — — WO disclosed
CN-118697922-A Perfume dispersing device 弗门尼舍有限公司 2024-09-27 — — CN disclosed
EP-3470407-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2024-01-24 — — EP disclosed
CN-109414048-B Coated yeast formulation 弗门尼舍有限公司 2023-09-01 — — CN disclosed
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