Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | FPR1 | P21462 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1398880 | 0.89 | TSHR (0.54) | HCRTR1HCRTR2TSHRRECQLSCN1A | |
| SCHEMBL3058143 | 0.87 | HCRTR1 (0.49) | HCRTR1HCRTR2TSHRRECQLFPR2 | |
| SCHEMBL3063294 | 0.86 | HCRTR2 (0.47) | SCN9AHCRTR1HCRTR2CDK4CCND1 | |
| SCHEMBL3065362 | 0.84 | MAOB (0.43) | CDK4CCND1MEN1ALDH1A1KMT2A | |
| SCHEMBL3309753 | 0.81 | SLC6A4 (0.42) | SCN9AHCRTR1HCRTR2SLC6A4SLC6A3 | |
| SCHEMBL1398915 | 0.81 | HCRTR1 (0.47) | HCRTR1HCRTR2MEN1ALDH1A1KMT2A | |
| SCHEMBL3058405 | 0.81 | HCRTR1 (0.55) | HCRTR1HCRTR2SLC6A4SLC6A3CDK4 | |
| SCHEMBL4784756 | 0.80 | PDK2 (0.51) | SCN9AHCRTR1HCRTR2FPR1FPR2 | |
| SCHEMBL3058144 | 0.79 | CDK4 (0.46) | HCRTR1HCRTR2CDK4CCND1TSHR | |
| SCHEMBL3063120 | 0.79 | ALDH1A1 (0.49) | HCRTR1HCRTR2TSHRCYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222600-A1 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222600-A1 | AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY1R | SCN9A 594/4885HCRTR1 2/4885HCRTR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.