Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ASPH | Q12797 | 1/20 | 0.44 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18367123 | 1.00 | MEN1 (0.52) | MEN1KMT2APKMALDH1A1KDM4E | |
| SCHEMBL30092730 | 0.88 | NPSR1 (0.46) | MEN1KMT2APKMALDH1A1SMN1; SMN2 | |
| SCHEMBL22888153 | 0.88 | NPSR1 (0.46) | MEN1KMT2APKMALDH1A1KDM4E | |
| SCHEMBL18367122 | 0.88 | NPSR1 (0.46) | MEN1KMT2APKMALDH1A1SMN1; SMN2 | |
| SCHEMBL25761671 | 0.85 | SMN1; SMN2 (0.42) | MEN1KMT2APKMALDH1A1SMN1; SMN2 | |
| SCHEMBL24310638 | 0.84 | MEN1 (0.46) | MEN1KMT2APKMALDH1A1KDM4E | |
| SCHEMBL18367125 | 0.83 | LMNA (0.47) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL30092739 | 0.80 | POLB (0.54) | MEN1KMT2AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL30434549 | 0.80 | RIPK1 (0.50) | MEN1KMT2AALDH1A1KDM4AKDM4C | |
| SCHEMBL18366877 | 0.80 | POLB (0.54) | MEN1KMT2AALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |