Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18366899 | 1.00 | KDM4C (0.49) | KDM4CL3MBTL1HDAC1HDAC6NPC1 | |
| SCHEMBL22737044 | 0.85 | HDAC1 (0.46) | KDM4CHDAC1HDAC6PTGER4PTGER2 | |
| SCHEMBL18366896 | 0.84 | L3MBTL1 (0.47) | L3MBTL1HDAC1HDAC6NPC1NFKB1 | |
| SCHEMBL30587599 | 0.84 | L3MBTL1 (0.47) | L3MBTL1HDAC1HDAC6NPC1NFKB1 | |
| SCHEMBL1414358 | 0.84 | KLKB1 (0.49) | HDAC1HDAC6RIPK1 | |
| SCHEMBL30092734 | 0.83 | HDAC1 (0.49) | KDM4CL3MBTL1HDAC1HDAC6NR4A2 | |
| SCHEMBL18366879 | 0.83 | HDAC1 (0.49) | KDM4CL3MBTL1HDAC1HDAC6NR4A2 | |
| SCHEMBL18366892 | 0.82 | HDAC1 (0.53) | KDM4CHDAC1HDAC6NPC1RAB9A | |
| SCHEMBL30092639 | 0.82 | CACNA1G (0.51) | HDAC1HDAC6SIGMAR1PTGER4P2RY14 | |
| SCHEMBL18366425 | 0.82 | CACNA1G (0.51) | HDAC1HDAC6SIGMAR1PTGER4P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |