Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 4/20 | 0.43 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30588379 | 1.00 | EPHA2 (0.43) | EPHA2HTR6BCHECHRM2CHRM4 | |
| SCHEMBL26117273 | 0.85 | CNR1 (0.36) | CNR1CNR2 | |
| SCHEMBL26115781 | 0.85 | CNR1 (0.36) | CNR1CNR2 | |
| SCHEMBL26115783 | 0.85 | CNR1 (0.36) | CNR1CNR2 | |
| SCHEMBL26116198 | 0.81 | HTR6 (0.48) | HTR6BCHECHRM2CHRM4CHRM1 | |
| SCHEMBL31076441 | 0.78 | UCHL1 (0.46) | EPHA2HTR6BCHEERBB2EPHB4 | |
| SCHEMBL25874576 | 0.77 | EPHA2 (0.44) | EPHA2ERBB2EPHB4GPR119USP2 | |
| SCHEMBL30781387 | 0.77 | EPHA2 (0.40) | EPHA2ERBB2EPHB4CNR1USP30 | |
| SCHEMBL27123179 | 0.77 | EPHA2 (0.40) | EPHA2ERBB2EPHB4CNR1USP30 | |
| SCHEMBL30781439 | 0.76 | EPHA2 (0.40) | EPHA2ERBB2EPHB4CSF1RUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4499628-A1 | 2,4-DIOXOTETRAHYDROPYRIMIDINYL DERIVATIVES AS DEGRONS IN PROTACS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2025-02-05 | — | — | EP | disclosed |
| WO-2023180388-A1 | 2,4-DIOXOTETRAHYDROPYRIMIDINYL DERIVATIVES AS DEGRONS IN PROTACS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-09-28 | — | — | WO | disclosed |