Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 3/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150796 | 0.90 | DRD2 (0.68) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| SCHEMBL30588460 | 0.83 | DRD2 (0.55) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| SCHEMBL1239171 | 0.83 | DRD2 (0.55) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL1239782 | 0.81 | DRD2 (0.54) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL31285909 | 0.81 | DRD2 (0.54) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| Alcohol SCHEMBL27483039 | 0.78 | SLC6A4 (0.58) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| SCHEMBL3139830 | 0.77 | DRD2 (0.78) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| SCHEMBL4777232 | 0.77 | HTR6 (0.52) | SLC6A4HTR2AHTR6 | |
| SCHEMBL7141854 | 0.75 | DRD2 (0.74) | DRD2SLC6A4OPRM1OPRK1OPRL1 | |
| SCHEMBL3144999 | 0.75 | DRD2 (0.66) | DRD2SLC6A4OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4499628-A1 | 2,4-DIOXOTETRAHYDROPYRIMIDINYL DERIVATIVES AS DEGRONS IN PROTACS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2025-02-05 | — | — | EP | disclosed |
| WO-2023180388-A1 | 2,4-DIOXOTETRAHYDROPYRIMIDINYL DERIVATIVES AS DEGRONS IN PROTACS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-09-28 | — | — | WO | disclosed |