Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17891713 | 1.00 | MMP13 (0.47) | MMP13AKR1C3AKR1C2KDM4CKDM5B | |
| SCHEMBL19383313 | 0.91 | AKR1C3 (0.48) | MMP13AKR1C3AKR1C2KDM4CKDM5B | |
| SCHEMBL17891695 | 0.86 | KDM4C (0.43) | MMP13AKR1C3AKR1C2KDM4CKDM5B | |
| SCHEMBL30589250 | 0.86 | KDM4C (0.43) | MMP13AKR1C3AKR1C2KDM4CKDM5B | |
| SCHEMBL30589245 | 0.84 | KDM4C (0.42) | MMP13AKR1C3AKR1C2KDM4CKDM5B | |
| SCHEMBL17891747 | 0.84 | MMP13 (0.47) | MMP13AKR1C3AKR1C2KDM4CKDM5B | |
| SCHEMBL17891739 | 0.84 | KDM4C (0.42) | MMP13AKR1C3AKR1C2KDM4CKDM5B | |
| SCHEMBL27848902 | 0.78 | AKR1C3 (0.55) | AKR1C3AKR1C2L3MBTL1ALDH1A1ALOX15 | |
| SCHEMBL17898983 | 0.76 | MMP13 (0.46) | MMP13AKR1C3AKR1C2TOP2AL3MBTL1 | |
| SCHEMBL19383312 | 0.75 | AKR1C3 (0.48) | MMP13AKR1C3AKR1C2KDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436445-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2023-09-06 | — | — | EP | disclosed |