Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26601889 | 1.00 | MAPK1 (0.46) | MAPK1KMT2ARAB9AGRM5MCL1 | |
| SCHEMBL26601883 | 0.80 | HTT (0.44) | MAPK1MCL1STAT3HTTSMN1; SMN2 | |
| SCHEMBL30593159 | 0.80 | HTT (0.44) | MAPK1MCL1STAT3HTTSMN1; SMN2 | |
| SCHEMBL30593154 | 0.78 | ABCB1 (0.43) | KMT2ARAB9AGRM5MCL1PTGER1 | |
| SCHEMBL26601782 | 0.78 | ABCB1 (0.43) | KMT2ARAB9AGRM5MCL1PTGER1 | |
| SCHEMBL31517782 | 0.74 | HTT (0.47) | MAPK1MCL1STAT3HTTSMN1; SMN2 | |
| SCHEMBL18792157 | 0.74 | MAPK1 (0.56) | MAPK1KMT2ARAB9AGRM5CASP3 | |
| SCHEMBL26601636 | 0.74 | HTT (0.44) | MAPK1MCL1PTGER1STAT3HTT | |
| SCHEMBL26601602 | 0.74 | SMN1; SMN2 (0.44) | MAPK1RAB9AMCL1PTGER1STAT3 | |
| SCHEMBL4781292 | 0.71 | HTT (0.54) | MAPK1GRM5MCL1STAT3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119546580-A | Heteroaryl compounds for the treatment of pain | 沃泰克斯药物股份有限公司 | 2025-02-28 | — | — | CN | disclosed |
| EP-4511115-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| EP-4511117-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| WO-2023205465-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |
| WO-2023205468-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |