Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26601782 | 1.00 | ABCB1 (0.43) | ABCB1RXFP1PTGER1RAB9AHTT | |
| SCHEMBL26608317 | 0.82 | MCL1 (0.46) | PTGER1RAB9AHTTMAPTMCL1 | |
| SCHEMBL26601663 | 0.81 | MCL1 (0.51) | PTGER1RAB9AHTTKMT2AMCL1 | |
| SCHEMBL31518041 | 0.81 | MCL1 (0.51) | PTGER1RAB9AHTTKMT2AMCL1 | |
| SCHEMBL31517882 | 0.80 | CA9 (0.49) | PTGER1HTTMAPTMCL1CA9 | |
| SCHEMBL26601691 | 0.80 | MCL1 (0.47) | PTGER1HTTMAPTMCL1 | |
| SCHEMBL26608461 | 0.79 | PTGER1 (0.47) | PTGER1HTTMAPTMCL1 | |
| SCHEMBL30593116 | 0.78 | MAPK1 (0.46) | PTGER1RAB9AHTTGRM5KMT2A | |
| SCHEMBL26601889 | 0.78 | MAPK1 (0.46) | PTGER1RAB9AHTTGRM5KMT2A | |
| SCHEMBL31336208 | 0.77 | RAB9A (0.50) | RAB9AMAPTKMT2AMCL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119546580-A | Heteroaryl compounds for the treatment of pain | 沃泰克斯药物股份有限公司 | 2025-02-28 | — | — | CN | disclosed |
| EP-4511115-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| EP-4511117-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| WO-2023205465-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |
| WO-2023205468-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |