Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059474 | 1.00 | MAPK1 (0.60) | MAPK1NLRP3SMN1; SMN2MAPTAKR1C3 | |
| SCHEMBL3062167 | 1.00 | MAPK1 (0.60) | MAPK1NLRP3SMN1; SMN2MAPTAKR1C3 | |
| SCHEMBL13219100 | 0.79 | MAPK1 (0.78) | MAPK1NLRP3SMN1; SMN2MAPTAKR1C3 | |
| SCHEMBL13091214 | 0.75 | MAPT (0.86) | MAPK1NLRP3SMN1; SMN2MAPTAKR1C3 | |
| SCHEMBL8239323 | 0.74 | MAPT (0.51) | SMN1; SMN2MAPTLMNAHTTPOLB | |
| SCHEMBL11913671 | 0.73 | DDX3X (0.82) | SMN1; SMN2MAPTLMNAHTTPOLB | |
| SCHEMBL19002884 | 0.73 | MAPT (0.60) | MAPK1NLRP3SMN1; SMN2MAPTAKR1C3 | |
| SCHEMBL22737771 | 0.72 | KMT2A (0.57) | SMN1; SMN2MAPTLMNAHTTPOLB | |
| SCHEMBL22737561 | 0.71 | GBA1 (0.49) | SMN1; SMN2MAPTLMNAHTTPOLB | |
| SCHEMBL11961916 | 0.71 | MAPT (0.79) | SMN1; SMN2MAPTAKR1C3AKR1C1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194783-A1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | VM Discovery, Inc. (US) | 2010-06-16 | — | — | EP | claimed |
| WO-2009023558-A1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | VM DISCOVERY INC. (US) | 2009-02-19 | — | — | WO | claimed |
| EP-2194783-B1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | VM DISCOVERY INC (US) | 2017-07-05 | — | — | EP | disclosed |
| US-8618110-B2 | Compositions and methods for apoptosis modulators | VM DISCOVERY INC. (US) | 2013-12-31 | — | — | US | disclosed |
| US-20100267671-A1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | VM DISCOVERY INC. | 2010-10-21 | — | — | US | disclosed |
| EP-2194783-A1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | VM Discovery, Inc. (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023558-A1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | VM DISCOVERY INC. (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267671-A1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | BAX, BCL2, BAD | MAPK1 2582/4885NLRP3 3087/4885SMN1; SMN2 1154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.