Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 4/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 4/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13485368 | 1.00 | HSD17B10 (0.47) | HSD17B10SYKADRB1GABRA1GABRG2 | |
| SCHEMBL30947585 | 0.86 | HSD17B10 (0.39) | HSD17B10SYKGABRA1GABRG2GABRB3 | |
| SCHEMBL16996827 | 0.82 | HRH4 (0.39) | HSD17B10SYKCCR1CCR5CCR8 | |
| SCHEMBL13485287 | 0.81 | GRM5 (0.43) | SYKADRB1RXRAGRIN1GRIN2B | |
| SCHEMBL4883101 | 0.80 | CCR1 (0.36) | HSD17B10SYKCCR1CCR5CCR8 | |
| SCHEMBL24920392 | 0.78 | CCR1 (0.35) | HSD17B10CCR1CCR5CCR8 | |
| SCHEMBL990141 | 0.76 | TRPV3 (0.46) | HSD17B10 | |
| Hydrochloric Acid SCHEMBL2181347 | 0.75 | SYK (0.40) | SYKRXRAGRIN1GRIN2BPLK4 | |
| SCHEMBL13347716 | 0.75 | PTGS2 (0.46) | SYKADRB1RXRAGRIN1GRIN2B | |
| SCHEMBL3665766 | 0.74 | BLM (0.47) | HSD17B10SYKALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116829546-A | Novel heteroaryl substituted imidazole derivatives | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |