Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.60 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.60 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.59 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.59 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.59 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5547174 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL3266475 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL29088008 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL5134179 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL5541245 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL6385117 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| SCHEMBL23141152 | 0.97 | PLA2G1B (0.62) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| SCHEMBL20746344 | 0.97 | PLA2G1B (0.62) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| SCHEMBL11289661 | 0.97 | PLA2G1B (0.62) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| SCHEMBL20746346 | 0.97 | PLA2G1B (0.62) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113694894-A | Porous fluid and preparation method and application thereof | 湖南大学 | 2021-11-26 | — | — | CN | claimed |
| CN-113694894-A | Porous fluid and preparation method and application thereof | 湖南大学 | 2021-11-26 | — | — | CN | disclosed |
| CN-113694894-A | Porous fluid and preparation method and application thereof | 湖南大学 | 2021-11-26 | — | — | CN | disclosed |
| US-20150076064-A1 | PROCESS FOR DEPLETING CALCIUM AND/OR IRON FROM GEOTHERMAL BRINES | MIDAMERICAN ENERGY HOLDINGS COMPANY | 2015-03-19 | — | — | US | disclosed |
| US-8894865-B2 | Process for depleting calcium and/or iron from geothermal brines | BERKSHIRE HATHAWAY ENERGY COMPANY (US) | 2014-11-25 | — | — | US | disclosed |
| US-20130068697-A1 | PROCESS FOR DEPLETING CALCIUM AND/OR IRON FROM GEOTHERMAL BRINES | MIDAMERICAN ENERGY HOLDINGS COMPANY (US) | 2013-03-21 | — | — | US | disclosed |
| US-8313653-B2 | Method of removing iron and calcium from a geothermal brine | MIDAMERICAN ENERGY HOLDINGS COMPANY (US) | 2012-11-20 | — | — | US | disclosed |
| US-20110049062-A1 | PROCESS FOR PRODUCING ELECTROLYTIC MANGANESE DIOXIDE | BERKSHIRE HATHAWAY ENERGY COMPANY | 2011-03-03 | — | — | US | disclosed |
| US-7776202-B2 | Extracting geothermal brine with organic solvent containing quaternary ammonium compound and acid; removing iron component by oxidization and precipitation; electrowinning | MIDAMERICAN ENERGY HOLDINGS COMPANY (US) | 2010-08-17 | — | — | US | disclosed |
| US-20040149590-A1 | Extracting geothermal brine with organic solvent containing quaternary ammonium compound and acid; removing iron component by oxidization and precipitation; electrowinning | BERKSHIRE HATHAWAY ENERGY COMPANY | 2004-08-05 | — | — | US | disclosed |
| US-6682644-B2 | EFFICIENT, MORE ENVIRONMENTALLY FRIENDLY SOLVENT EXTRACTION AND ELECTROWINNING TECHNIQUE | MIDAMERICAN ENERGY HOLDINGS COMPANY | 2004-01-27 | — | — | US | disclosed |
| US-20030226761-A1 | EFFICIENT, MORE ENVIRONMENTALLY FRIENDLY SOLVENT EXTRACTION AND ELECTROWINNING TECHNIQUE | BERKSHIRE HATHAWAY ENERGY COMPANY | 2003-12-11 | — | — | US | disclosed |
| WO-2003102272-A1 | PROCESS FOR PRODUCING ELECTROLYTIC MANGANESE DIOXIDE FROM GEOTHERMAL BRINES | MIDAMERICAN ENERGY HOLDINGS COMPANY (US) | 2003-12-11 | — | — | WO | disclosed |