Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.60 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.60 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.59 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.59 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.59 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5547174 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL3266475 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL3059784 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL29088008 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL5134179 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| Bromide SCHEMBL6385117 | 1.00 | PLA2G1B (0.60) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| SCHEMBL23141152 | 0.97 | PLA2G1B (0.62) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| SCHEMBL20746344 | 0.97 | PLA2G1B (0.62) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| SCHEMBL11289661 | 0.97 | PLA2G1B (0.62) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 | |
| SCHEMBL20746346 | 0.97 | PLA2G1B (0.62) | PLA2G1BPLA2G2AS1PR2S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214102-A | Amine-containing transfection reagents and methods of making and using same | 生命技术公司 | 2021-08-06 | — | — | CN | claimed |
| CN-108358812-B | Amine-containing transfection reagents and methods of making and using same | 生命技术公司 | 2021-05-11 | — | — | CN | claimed |
| CN-104324047-A | New complex medical iodine disinfectant and preparation method thereof | UNIV TIANJIN | 2015-02-04 | — | — | CN | claimed |
| CN-114761376-A | Amine-containing transfection reagent, preparation method and transfection compound | 苏州瑞博生物技术股份有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-113214102-A | Amine-containing transfection reagents and methods of making and using same | 生命技术公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-113075186-A | Method for detecting zinc dimethyldithiocarbamate based on cesium-lead-bromine quantum dots | 泉州师范学院 | 2021-07-06 | — | — | CN | disclosed |
| CN-108358812-B | Amine-containing transfection reagents and methods of making and using same | 生命技术公司 | 2021-05-11 | — | — | CN | disclosed |
| CN-111246821-A | Light absorbing compositions and methods of use | 美国绿阳生物技术及医药公司 | 2020-06-05 | — | — | CN | disclosed |
| CN-105189531-B | Peptides for skin rejuvenation and methods of use thereof | 安特易斯有限公司 | 2020-02-21 | — | — | CN | disclosed |
| CN-107441502-A | A kind of nano-particle for carrying combination drug composition | 首都医科大学附属北京安贞医院 | 2017-12-08 | — | — | CN | disclosed |
| CN-104324047-A | New complex medical iodine disinfectant and preparation method thereof | UNIV TIANJIN | 2015-02-04 | — | — | CN | disclosed |
| US-20070233024-A1 | Sanitary Thin Paper and Process for Producing the Same | DAIO PAPER CORPORATION | 2007-10-04 | — | — | US | disclosed |
| EP-1752580-A1 | SANITARY THIN PAPER AND PROCESS FOR PRODUCING THE SAME | Daio Paper Corporation (JP) | 2007-02-14 | — | — | EP | disclosed |
| US-5455157-A | Introducing nucleotide labelled with hapten into cell with addition of nonencapsulating cationic liposome, determining incorporation into nucleic acids as function of time | BOEHRINGER MANNHEIM GMBH (DE) | 1995-10-03 | — | — | US | disclosed |
| US-4902512-A | Rhamnolipid liposomes | DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY AND SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1990-02-20 | — | — | US | disclosed |