Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30009820 | 0.81 | HPGD (0.57) | ABL1HPGDJAK1NPC1RAB9A | |
| SCHEMBL30597983 | 0.80 | SLC5A1 (0.39) | ABL1HPGD | |
| SCHEMBL30597949 | 0.79 | SLC5A1 (0.39) | ABL1HPGDJAK1JAK2NPC1 | |
| SCHEMBL29697316 | 0.78 | ROCK2 (0.51) | ABL1HPGDNPC1RAB9A | |
| SCHEMBL21961535 | 0.73 | CTSC (0.38) | ABL1HPGDJAK1NPC1RAB9A | |
| SCHEMBL21874330 | 0.71 | APP (0.41) | MEN1KMT2AHPGDNPC1RAB9A | |
| SCHEMBL2222163 | 0.69 | POLB (0.63) | SMN1; SMN2MEN1KMT2APOLBHPGDS | |
| SCHEMBL2222173 | 0.69 | POLB (0.63) | SMN1; SMN2MEN1KMT2APOLBHPGDS | |
| SCHEMBL2334270 | 0.68 | MEN1 (0.61) | SMN1; SMN2MEN1KMT2APOLBHPGDS | |
| SCHEMBL29549442 | 0.68 | MEN1 (0.61) | SMN1; SMN2MEN1KMT2APOLBHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010080-B1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LTD (GB) | 2023-09-27 | — | — | EP | claimed |