Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15404492 | 0.88 | POLB (0.54) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL30988391 | 0.79 | HSD11B1 (0.46) | HSD11B1ALDH1A1ELANECA12CA1 | |
| SCHEMBL6182656 | 0.79 | POLB (0.53) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL31148931 | 0.77 | POLB (0.48) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL9364060 | 0.77 | POLB (0.48) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL28909141 | 0.76 | POLB (0.45) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL9745499 | 0.76 | CYP1A2 (0.48) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL14958316 | 0.75 | CYP1A2 (0.50) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL28193046 | 0.75 | POLB (0.46) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL7470086 | 0.73 | POLB (0.44) | POLBCYP1A2CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116813622-A | Chimeric body based on molecular chaperone HSP90 mediated targeted degradation GPX4 and preparation method and application thereof | 中国科学院基础医学与肿瘤研究所(筹) | 2023-09-29 | — | — | CN | disclosed |