Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Nor-Noha. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 known ✓ | P35228 | 14/20 | 0.53 |
| ▸ | NOS1 known ✓ | P29475 | 12/20 | 0.53 |
| ▸ | NOS3 known ✓ | P29474 | 9/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nor-Noha SCHEMBL29499929 | 0.95 | NOS2 (0.52) | NOS2NOS1NOS3CYP2C19MEN1 | |
| Nor-Noha SCHEMBL29414881 | 0.95 | NOS2 (0.52) | NOS2NOS1NOS3CYP2C19MEN1 | |
| Acetic Acid SCHEMBL29386173 | 0.90 | NOS2 (0.68) | NOS2NOS1NOS3CYP2C19MEN1 | |
| SCHEMBL1736698 | 0.84 | NOS2 (0.68) | NOS2NOS1NOS3CYP2C19MEN1 | |
| SCHEMBL1736695 | 0.84 | NOS2 (0.68) | NOS2NOS1NOS3CYP2C19MEN1 | |
| SCHEMBL21068035 | 0.76 | NOS2 (0.41) | NOS2NOS1NOS3CYP2C19MEN1 | |
| SCHEMBL1738239 | 0.75 | NOS2 (0.77) | NOS2NOS1NOS3CYP2C19MEN1 | |
| SCHEMBL22344274 | 0.75 | NOS2 (0.77) | NOS2NOS1NOS3CYP2C19MEN1 | |
| Tilarginine SCHEMBL23099403 | 0.74 | NOS1 (0.69) | NOS2NOS1NOS3CYP2C19MEN1 | |
| Arginine SCHEMBL31591103 | 0.71 | NOS2 (0.89) | NOS2NOS1NOS3CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250099408-A1 | IMPROVED SURAMIN METHODS AND COMPOSITIONS | OPIYO SAMMY OYOO (KE) | 2025-03-27 | — | — | US | disclosed |
| CN-117797084-A | Hydrogel stent and preparation method and application thereof | 苏州大学 | 2024-04-02 | — | — | CN | disclosed |
| WO-2023191116-A2 | IMPROVED SURAMIN METHODS AND COMPOSITIONS | OPIYO SAMMY OYOO (KE) | 2023-10-05 | — | — | WO | disclosed |