Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 3/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23068567 | 1.00 | PDE4D (0.43) | PDE4DTNFEGLN1HTR2AHTR2C | |
| SCHEMBL23068564 | 1.00 | PDE4D (0.43) | PDE4DTNFEGLN1HTR2AHTR2C | |
| SCHEMBL12921369 | 0.92 | PDE4D (0.37) | PDE4DEGLN1HTR2A | |
| SCHEMBL30607014 | 0.91 | PDE4D (0.51) | PDE4DTNFHTR2AHTR2CHTR2B | |
| SCHEMBL23068553 | 0.91 | PDE4D (0.51) | PDE4DTNFHTR2AHTR2CHTR2B | |
| SCHEMBL23068551 | 0.91 | PDE4D (0.51) | PDE4DTNFHTR2AHTR2CHTR2B | |
| SCHEMBL30607013 | 0.86 | PDE4D (0.47) | PDE4DTNFEGLN1PDE10A | |
| SCHEMBL23068587 | 0.86 | PDE4D (0.47) | PDE4DTNFEGLN1PDE10A | |
| SCHEMBL23068586 | 0.86 | PDE4D (0.47) | PDE4DTNFEGLN1PDE10A | |
| SCHEMBL12209704 | 0.84 | PDE4D (0.37) | PDE4DTNFPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111712502-B | Substituted azetidine dihydro-thienopyrimidines and their use as phosphodiesterase inhibitors | 联合疗法公司 | 2023-10-27 | — | — | CN | claimed |
| CN-111712502-B | Substituted azetidine dihydro-thienopyrimidines and their use as phosphodiesterase inhibitors | 联合疗法公司 | 2023-10-27 | — | — | CN | disclosed |