Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25875488 | 0.83 | ALDH1A1 (0.38) | PPARAPPARDMAPTMEN1KMT2A | |
| SCHEMBL4323037 | 0.79 | CYP2A6 (0.38) | MAPTMEN1KMT2ANPSR1RAB9A | |
| SCHEMBL77569 | 0.79 | MEN1 (0.41) | PPARAPPARDMAPTMEN1KMT2A | |
| SCHEMBL1230294 | 0.79 | CYP2A6 (0.38) | MAPTMEN1KMT2ANPSR1RAB9A | |
| SCHEMBL16546592 | 0.79 | ALDH1A1 (0.40) | PPARAPPARDMAPTMEN1KMT2A | |
| SCHEMBL11716929 | 0.77 | MAPT (0.37) | MAPTMEN1KMT2ANPSR1RAB9A | |
| SCHEMBL23149109 | 0.75 | ALDH1A1 (0.38) | PPARAPPARDMAPTMEN1KMT2A | |
| SCHEMBL21791780 | 0.73 | CA1 (0.38) | MAPTALDH1A1KDM4ELDHACYP2A6 | |
| SCHEMBL1006518 | 0.73 | ALDH1A1 (0.42) | PPARAPPARDMAPTMEN1KMT2A | |
| SCHEMBL9243983 | 0.73 | ALDH1A1 (0.42) | PPARAPPARDMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119546604-A | Pyrido [3,2-D ] pyrimidines as HPK1 inhibitors | 默克专利有限公司 | 2025-02-28 | — | — | CN | disclosed |
| EP-4507789-A1 | PYRIDO[3,2-D]PYRIMIDINES AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-02-19 | — | — | EP | disclosed |
| WO-2023201185-A1 | PYRIDO[3,2-D]PYRIMIDINES AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-10-19 | — | — | WO | disclosed |