SCHEMBL30616405

SCHEMBL30616405

C#CCn1c(=O)c([N+](=O)[O-])c(N2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c2nc(C#N)ccc21

nearest known ligand 0.76

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ DGKA P23743 18/20 0.76
▸ DGKZ Q13574 18/20 0.76
▸ DGKI O75912 3/20 0.76
▸ DGKG P49619 2/20 0.76
▸ DGKB Q9Y6T7 2/20 0.76
▸ DGKK Q5KSL6 1/20 0.76
▸ MGLL Q99685 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23293461 1.00 DGKA (0.76) DGKADGKZDGKIDGKGDGKB
SCHEMBL23293193 0.94 DGKA (0.79) DGKADGKZDGKIDGKGDGKB
SCHEMBL30616406 0.94 DGKA (0.79) DGKADGKZDGKIDGKGDGKB
SCHEMBL30616404 0.92 DGKZ (0.67) DGKADGKZDGKIDGKGDGKB
SCHEMBL23293410 0.92 DGKZ (0.67) DGKADGKZDGKIDGKGDGKB
SCHEMBL23293427 0.91 DGKA (0.64) DGKADGKZDGKIDGKGDGKB
SCHEMBL23293504 0.91 DGKA (0.64) DGKADGKZDGKIDGKGDGKB
SCHEMBL23293219 0.91 DGKA (0.65) DGKADGKZDGKIDGKGDGKB
SCHEMBL23293421 0.91 DGKZ (0.65) DGKADGKZDGKIDGKGDGKB
SCHEMBL23293208 0.90 DGKZ (0.62) DGKADGKZDGKIDGKGDGKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112585139-B Naphthyridinone compounds as T cell activators 百时美施贵宝公司 2023-12-01 — — CN claimed
CN-112585139-B Naphthyridinone compounds as T cell activators 百时美施贵宝公司 2023-12-01 — — CN disclosed
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