Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 19/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29097712 | 1.00 | PTPN11 (0.46) | PTPN11KCNH2SMN1; SMN2MAPK3MAPK1 | |
| SCHEMBL29097721 | 0.78 | HCRTR2 (0.38) | PTPN11SMN1; SMN2 | |
| SCHEMBL1935226 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2 | |
| SCHEMBL1935622 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPK1 | |
| SCHEMBL1491746 | 0.77 | SMN1; SMN2 (0.71) | SMN1; SMN2 | |
| SCHEMBL31318204 | 0.76 | HCRTR2 (0.39) | SMN1; SMN2 | |
| SCHEMBL1935919 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPK1 | |
| SCHEMBL29097722 | 0.75 | PTPN11 (0.39) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL30621964 | 0.75 | PTPN11 (0.39) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL30919741 | 0.74 | HCRTR2 (0.47) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4745132-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Technoderma Medicines Inc. (CN) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025011447-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 特科罗生物科技(成都)有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-116903592-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-10-20 | — | — | CN | disclosed |