Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 19/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29097722 | 1.00 | PTPN11 (0.39) | PTPN11KCNH2MAPK3MAPK1PDCD1 | |
| SCHEMBL29097567 | 0.80 | PDCD1 (0.33) | PTPN11PDCD1CD274 | |
| SCHEMBL30621970 | 0.75 | SCN9A (0.34) | — | |
| SCHEMBL29097706 | 0.75 | SCN9A (0.34) | — | |
| SCHEMBL30621967 | 0.75 | PTPN11 (0.46) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL29097712 | 0.75 | PTPN11 (0.46) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL31318205 | 0.73 | STK17B (0.46) | PDCD1CD274 | |
| SCHEMBL29097568 | 0.72 | DPP4 (0.32) | — | |
| SCHEMBL30621963 | 0.72 | DPP4 (0.32) | — | |
| SCHEMBL3661082 | 0.66 | SMN1; SMN2 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025011447-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 特科罗生物科技(成都)有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-116903592-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-10-20 | — | — | CN | disclosed |