Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.57 |
| ▸ | JAK2 | O60674 | 3/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.57 |
| ▸ | INSR | P06213 | 4/20 | 0.55 |
| ▸ | IGF1R | P08069 | 3/20 | 0.55 |
| ▸ | TTK | P33981 | 1/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29097707 | 1.00 | EGFR (0.59) | EGFRALKJAK2SRCTNK2 | |
| SCHEMBL29097555 | 0.88 | EGFR (0.54) | EGFRALKJAK2SRCTNK2 | |
| SCHEMBL29097557 | 0.85 | EGFR (0.54) | EGFRALKJAK2SRCTNK2 | |
| SCHEMBL31318199 | 0.84 | ALK (0.54) | EGFRALKMAP3K7 | |
| SCHEMBL30621972 | 0.84 | ALK (0.57) | ALKJAK2SRCTNK2IGF1R | |
| SCHEMBL29097716 | 0.84 | ALK (0.57) | ALKJAK2SRCTNK2IGF1R | |
| SCHEMBL29097720 | 0.84 | EGFR (0.51) | EGFRALKJAK2SRCTNK2 | |
| SCHEMBL18491223 | 0.80 | EGFR (0.73) | EGFRALKJAK2SRCTNK2 | |
| SCHEMBL29791446 | 0.76 | EGFR (0.63) | EGFRALKJAK2SRCTNK2 | |
| SCHEMBL20398846 | 0.75 | ALK (0.75) | EGFRALKJAK2SRCTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025011447-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 特科罗生物科技(成都)有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-116903592-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-10-20 | — | — | CN | disclosed |