Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.57 |
| ▸ | CDK9 | P50750 | 4/20 | 0.52 |
| ▸ | CCNK | O75909 | 3/20 | 0.52 |
| ▸ | CCND3 | P30281 | 3/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 9/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29097716 | 1.00 | ALK (0.57) | ALKCDK9CCNKCCND3CDK6 | |
| SCHEMBL29097715 | 0.86 | SLC2A1 (0.51) | ALKCDK9CCNKCCND3CDK6 | |
| SCHEMBL29097707 | 0.84 | EGFR (0.59) | ALKTNK2JAK2IGF1RMAP3K7 | |
| SCHEMBL30621968 | 0.84 | EGFR (0.59) | ALKTNK2JAK2IGF1RMAP3K7 | |
| SCHEMBL29097550 | 0.83 | BRD4 (0.56) | ALKCDK9CCNKCCND3CDK6 | |
| SCHEMBL31318206 | 0.81 | MAP3K7 (0.47) | ALKCDK9CCNKCCND3CDK6 | |
| SCHEMBL25068891 | 0.81 | ALK (0.68) | ALKCDK9CCNKCCND3CDK6 | |
| SCHEMBL29097572 | 0.81 | MAP3K7 (0.47) | ALKCDK9CCNKCCND3CDK6 | |
| SCHEMBL23704663 | 0.77 | ALK (0.74) | ALKCDK9CCNKCCND3CDK6 | |
| SCHEMBL30331219 | 0.77 | ALK (0.74) | ALKCDK9CCNKCCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025011447-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 特科罗生物科技(成都)有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-116903592-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-10-20 | — | — | CN | disclosed |