Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | SORD | Q00796 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29097705 | 1.00 | TRPV1 (0.41) | TRPV1SMOPARGHRH3OGA | |
| SCHEMBL29097714 | 0.79 | ABL1 (0.39) | SMOPARG | |
| SCHEMBL30621965 | 0.79 | ABL1 (0.39) | SMOPARG | |
| SCHEMBL23276938 | 0.78 | JAK2 (0.60) | — | |
| SCHEMBL29097558 | 0.77 | JAK2 (0.53) | — | |
| SCHEMBL30621971 | 0.77 | JAK2 (0.53) | — | |
| SCHEMBL7390806 | 0.76 | TRPV1 (0.49) | TRPV1OGASORD | |
| SCHEMBL20361410 | 0.75 | TRPV1 (0.46) | TRPV1HRH3OGASORD | |
| SCHEMBL7395300 | 0.73 | PTPN11 (0.48) | HRH3 | |
| SCHEMBL7391819 | 0.73 | TRPV1 (0.44) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4745132-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Technoderma Medicines Inc. (CN) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025011447-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 特科罗生物科技(成都)有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-116903592-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-10-20 | — | — | CN | disclosed |