Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.39 |
| ▸ | BCR | P11274 | 7/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 3/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | PARG | Q86W56 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29097714 | 1.00 | ABL1 (0.39) | ABL1BCRHCRTR2CNR1CNR2 | |
| SCHEMBL30621970 | 0.81 | SCN9A (0.34) | SMOBRD4PARG | |
| SCHEMBL29097706 | 0.81 | SCN9A (0.34) | SMOBRD4PARG | |
| SCHEMBL29097705 | 0.79 | TRPV1 (0.41) | SMOPARG | |
| SCHEMBL30621975 | 0.79 | TRPV1 (0.41) | SMOPARG | |
| SCHEMBL29097718 | 0.79 | BRD4 (0.59) | ABL1BRD4 | |
| SCHEMBL31318204 | 0.76 | HCRTR2 (0.39) | ABL1BCRHCRTR2CNR1CNR2 | |
| SCHEMBL30621967 | 0.73 | PTPN11 (0.46) | SMN1; SMN2 | |
| SCHEMBL29097712 | 0.73 | PTPN11 (0.46) | SMN1; SMN2 | |
| SCHEMBL30621978 | 0.72 | HCRTR2 (0.37) | ABL1BCRHCRTR2CNR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4745132-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Technoderma Medicines Inc. (CN) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025011447-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 特科罗生物科技(成都)有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-116903592-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-10-20 | — | — | CN | disclosed |