Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.49 |
| ▸ | OGA | O60502 | 1/20 | 0.40 |
| ▸ | SORD | Q00796 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7391819 | 0.83 | TRPV1 (0.44) | TRPV1 | |
| SCHEMBL7393573 | 0.81 | HTR3E (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7386664 | 0.80 | PANK3 (0.48) | — | |
| SCHEMBL20361410 | 0.79 | TRPV1 (0.46) | TRPV1OGASORD | |
| SCHEMBL7395300 | 0.76 | PTPN11 (0.48) | — | |
| SCHEMBL30621975 | 0.76 | TRPV1 (0.41) | TRPV1OGASORD | |
| SCHEMBL29097705 | 0.76 | TRPV1 (0.41) | TRPV1OGASORD | |
| SCHEMBL7384813 | 0.75 | KDM4E (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL21193615 | 0.75 | TRPV1 (0.62) | TRPV1SORD | |
| Fumaric Acid SCHEMBL8697083 | 0.75 | TRPV1 (0.45) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723611-A | Heteroarylpiperidines | SANOFI (FR) | 1998-03-03 | — | — | US | disclosed |
| US-5595994-A | 1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1997-01-21 | — | — | US | disclosed |
| US-5502063-A | 1-halopyridin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |
| EP-0647639-A1 | Heteroarylpiperidines, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-04-12 | — | — | EP | disclosed |