Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | CTPS1 | P17812 | 8/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 2/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25355967 | 1.00 | ABL1 (0.39) | ABL1MAP4K1CTPS1PTGS1PTGS2 | |
| SCHEMBL30623231 | 0.77 | KDM4E (0.40) | ABL1MAP4K1CTPS1PTGS1PTGS2 | |
| SCHEMBL25359599 | 0.77 | KDM4E (0.40) | ABL1MAP4K1CTPS1PTGS1PTGS2 | |
| SCHEMBL25358409 | 0.77 | KDM4E (0.43) | ABL1MAP4K1CTPS1PTGS1PTGS2 | |
| SCHEMBL3123445 | 0.77 | KDM4E (0.40) | ABL1MAP4K1CTPS1PTGS1PTGS2 | |
| SCHEMBL29883804 | 0.77 | KDM4E (0.40) | ABL1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL28420434 | 0.77 | KDM4E (0.40) | ABL1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL29955212 | 0.73 | HCAR3 (0.56) | ALDH1A1 | |
| SCHEMBL3123439 | 0.73 | NNMT (0.54) | — | |
| SCHEMBL15653596 | 0.72 | PIK3CA (0.41) | PTGS1PTGS2TDP1CKS1BSKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119343353-A | 2-Methyl-4 ',5' -dihydrospiro [ piperidine-4, 7' -thieno [2,3-c ] pyran ] derivatives as APOL1 inhibitors and methods of use thereof | 弗特克斯药品有限公司 | 2025-01-21 | — | — | CN | disclosed |
| EP-4476227-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | Vertex Pharmaceuticals Incorporated (US) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |