Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30632896 | 0.84 | HTR2A (0.40) | NPC1RAB9AMAOBMAPTMEN1 | |
| SCHEMBL30633073 | 0.84 | NPC1 (0.36) | NPC1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL30632929 | 0.80 | MAPT (0.53) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL30632990 | 0.76 | KDM4E (0.47) | NPC1RAB9AMAOBLMNAMAPT | |
| SCHEMBL15870902 | 0.74 | — | — | |
| SCHEMBL30632897 | 0.71 | NFE2L2 (0.50) | — | |
| SCHEMBL28838566 | 0.70 | NPC1 (0.43) | NPC1RAB9AMAOBLMNASMN1; SMN2 | |
| SCHEMBL28838565 | 0.70 | NPC1 (0.43) | NPC1RAB9AMAOBLMNASMN1; SMN2 | |
| SCHEMBL5753891 | 0.70 | MAPT (0.41) | NPC1RAB9AMAOBLMNASMN1; SMN2 | |
| SCHEMBL5753887 | 0.70 | MAPT (0.41) | NPC1RAB9AMAOBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111886234-B | Heterocyclic mitochondrial activity inhibitors and uses thereof | 蒙特利尔大学 | 2023-12-15 | — | — | CN | disclosed |