Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 9/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17644865 | 1.00 | GABRA2 (0.42) | GABRA2GABRB2POLBALDH1A1LMNA | |
| SCHEMBL17644855 | 0.89 | GABRA2 (0.42) | GABRA2GABRB2POLBALDH1A1LMNA | |
| SCHEMBL24624555 | 0.86 | GPR119 (0.40) | GABRA2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL29772920 | 0.86 | GPR119 (0.40) | GABRA2GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL16971673 | 0.83 | NOTUM (0.45) | KCNMA1 | |
| SCHEMBL30271680 | 0.83 | NOTUM (0.45) | KCNMA1 | |
| SCHEMBL16971694 | 0.83 | NOTUM (0.37) | KCNMA1 | |
| Bromide SCHEMBL29491785 | 0.82 | NOTUM (0.36) | KCNMA1 | |
| Bromide SCHEMBL16974640 | 0.82 | NOTUM (0.36) | KCNMA1 | |
| SCHEMBL16971865 | 0.81 | NOTUM (0.39) | KCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4286372-A2 | PYRIMIDINONES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2023-12-06 | — | — | EP | disclosed |
| EP-3828186-B1 | PYRIMIDINONES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-23 | — | — | EP | disclosed |