Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 8/20 | 0.45 |
| ▸ | CNR1 | P21554 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 4/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3076047 | 0.92 | MAPK1 (0.51) | TSHRCNR2CNR1ALDH1A1HTT | |
| SCHEMBL3063431 | 0.84 | HSD11B1 (0.50) | HSD11B1MEN1ALDH1A1GAAKMT2A | |
| SCHEMBL3070635 | 0.82 | CNR2 (0.48) | TSHRCNR2CNR1ALDH1A1HTT | |
| SCHEMBL3067236 | 0.82 | CASR (0.48) | TSHRCNR2CNR1ALDH1A1HTT | |
| SCHEMBL3074521 | 0.81 | CNR2 (0.49) | TSHRCNR2CNR1ALDH1A1HTT | |
| SCHEMBL3080921 | 0.81 | CNR2 (0.48) | TSHRCNR2CNR1ALDH1A1HTT | |
| SCHEMBL3073920 | 0.81 | USP2 (0.53) | MEN1ALDH1A1GAAKMT2AKDM4E | |
| SCHEMBL3057487 | 0.80 | CNR2 (0.50) | CNR2CNR1CASR | |
| SCHEMBL3063101 | 0.79 | CNR2 (0.49) | CNR2CNR1ALDH1A1HTTFAAH | |
| SCHEMBL3066175 | 0.77 | CNR2 (0.52) | TSHRCNR2CNR1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178845-B1 | INHIBITORS OF 11B-HYDROXYSTEROID DEHYDROGENASE | HOFFMANN LA ROCHE (CH) | 2013-06-19 | — | — | EP | claimed |
| EP-2178845-A2 | INHIBITORS OF 11B-HYDROXYSTEROID DEHYDROGENASE | F. Hoffmann-Roche AG (CH) | 2010-04-28 | — | — | EP | claimed |
| WO-2009010416-A2 | INHIBITORS OF 11B-HYDROXYSTEROID DEHYDROGENASE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-22 | — | — | WO | claimed |
| EP-2178845-B1 | INHIBITORS OF 11B-HYDROXYSTEROID DEHYDROGENASE | HOFFMANN LA ROCHE (CH) | 2013-06-19 | — | — | EP | disclosed |
| US-7790711-B2 | Inhibitors of 11β-Hydroxysteroid Dehydrogenase | HOFFMANN-LA ROCHE INC. (US) | 2010-09-07 | — | — | US | disclosed |
| EP-2178845-A2 | INHIBITORS OF 11B-HYDROXYSTEROID DEHYDROGENASE | F. Hoffmann-Roche AG (CH) | 2010-04-28 | — | — | EP | disclosed |
| US-20090023709-A1 | Inhibitors of 11B-Hyrdoxysteroid Dehydrogenase | GILLESPIE PAUL | 2009-01-22 | — | — | US | disclosed |
| WO-2009010416-A2 | INHIBITORS OF 11B-HYDROXYSTEROID DEHYDROGENASE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023709-A1 | Inhibitors of 11B-Hyrdoxysteroid Dehydrogenase | HSD17B1, HSD17B2, HSD11B1 | TSHR 2797/4885CYP17A1 22/4885CYP19A1 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.