Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.58 |
| ▸ | METAP1 | P53582 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 4/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058561 | 0.88 | METAP2 (0.52) | METAP2METAP1NPC1ALDH1A1PKM | |
| SCHEMBL13137746 | 0.83 | METAP2 (0.56) | METAP2METAP1NPC1ALDH1A1PKM | |
| SCHEMBL680854 | 0.78 | METAP2 (0.65) | METAP2METAP1NPC1ALDH1A1RAB9A | |
| SCHEMBL27233072 | 0.77 | KDM4E (0.58) | METAP2METAP1RAB9ANPY5RPDE5A | |
| SCHEMBL4054706 | 0.77 | HPGD (0.55) | NPC1ALDH1A1PKMRAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL4456676 | 0.76 | METAP2 (0.63) | METAP2METAP1NPC1ALDH1A1RAB9A | |
| SCHEMBL3063543 | 0.76 | NPC1 (0.54) | NPC1ALDH1A1PKMRAB9AL3MBTL1 | |
| SCHEMBL4054645 | 0.75 | CYP3A4 (0.58) | NPC1ALDH1A1PKMRAB9AL3MBTL1 | |
| SCHEMBL369485 | 0.75 | METAP2 (0.61) | METAP2METAP1NPC1ALDH1A1PKM | |
| SCHEMBL541991 | 0.74 | ALDH1A1 (0.69) | METAP2METAP1NPC1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790730-B2 | Imidazo[4,5-d]pyrimidines, their uses and methods of preparation | GILEAD SCIENCES, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-7790730-B2 | Imidazo[4,5-d]pyrimidines, their uses and methods of preparation | GILEAD SCIENCES, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-7790730-B2 | Imidazo[4,5-d]pyrimidines, their uses and methods of preparation | GILEAD SCIENCES, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20090208456-A1 | Imidazo[4,5-d]pyrimidines, their uses and methods of preparation | GILEAD SCIENCES, INC. (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090208456-A1 | Imidazo[4,5-d]pyrimidines, their uses and methods of preparation | GILEAD SCIENCES, INC. (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090208456-A1 | Imidazo[4,5-d]pyrimidines, their uses and methods of preparation | GILEAD SCIENCES, INC. (US) | 2009-08-20 | — | — | US | disclosed |
| CN-101027303-A | Imidazo [4, 5-d ] pyrimidines, their use and processes for their preparation | GILEAD SCIENCES INC (US) | 2007-08-29 | — | — | CN | disclosed |
| EP-1781658-A1 | IMIDAZOÝ4,5-D¨PYRIMIDINES, THEIR USES AND METHODS OF PREPARATION | GILEAD SCIENCES, INC. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006033703-A1 | IMIDAZO[4,5-D]PYRIMIDINES, THEIR USES AND METHODS OF PREPARATION | GILEAD SCIENCES, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
| US-20060052602-A1 | Imidazo[4,5-d]pyrimidines, their uses and methods of preparation | GILEAD SCIENCES, INC. | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052602-A1 | Imidazo[4,5-d]pyrimidines, their uses and methods of preparation | TYMP, DPYD, TYMS | METAP2 1966/4885METAP1 1933/4885NPC1 1649/4885 |
| US-20090208456-A1 | Imidazo[4,5-d]pyrimidines, their uses and methods of preparation | TYMP, DPYD, TYMS | METAP2 1891/4885METAP1 1842/4885NPC1 1571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.