Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.36 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26629378 | 0.90 | TYK2 (0.39) | ALKTYK2LRRK2JAK1JAK2 | |
| SCHEMBL30412226 | 0.88 | HDAC1 (0.45) | HDAC1PARP1RETGPR119MAPK8 | |
| SCHEMBL30635595 | 0.86 | ALK (0.43) | HDAC1RETGPR119MAPK8ALK | |
| SCHEMBL30412718 | 0.86 | ALK (0.43) | HDAC1RETGPR119MAPK8ALK | |
| SCHEMBL30635690 | 0.84 | HDAC1 (0.45) | HDAC1PARP1RETGPR119MAPK8 | |
| SCHEMBL30635607 | 0.83 | ALK (0.44) | HDAC1PARP1GPR119MAPK8ALK | |
| SCHEMBL10205822 | 0.82 | ALK (0.54) | ALKEGFRERBB2ERBB3ERBB4 | |
| SCHEMBL30411996 | 0.82 | HDAC1 (0.43) | HDAC1PARP1RETGPR119MAPK8 | |
| SCHEMBL30410928 | 0.81 | ALK (0.43) | HDAC1PARP1GPR119MAPK8ALK | |
| SCHEMBL30412450 | 0.81 | ALK (0.43) | HDAC1PARP1GPR119MAPK8ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |